Disialoganglioside GD2 CAS 65988-71-8

Disialoganglioside GD2 CAS 65988-71-8

Product Name

Disialoganglioside GD2

CAS Number

65988-71-8

Chemical Formula

C74H134N4O32

Molecular Weight

1,642.7 g/mol

Synonyms and Aliases

• GD2 ganglioside
• Disialoganglioside GD2 glycolipid
• Tumor-associated ganglioside GD2
• Neuroblastoma biomarker GD2

Key Product Highlights

Disialoganglioside GD2 is a complex glycolipid notable for its distinct chemical structure and critical role as a tumor-associated antigen in cancer research. Its reliable chemical profile and biological relevance make GD2 a preferred target for monoclonal antibody therapies and immunotherapy development.

This high-purity GD2 ganglioside (CAS 65988-71-8) is manufactured under strict quality standards, ensuring consistent performance in oncology biomarker studies, biochemical assays, and pharmaceutical applications. Its molecular weight and formula confirm the structural integrity essential for research-grade material.

For industries working with GD2 glycolipids, this product provides a dependable foundation for advancing cancer research and novel therapeutic strategies.

GD2 Structure and Biochemical Nature

Disialoganglioside GD2 (CAS 65988-71-8) is a complex glycolipid composed of a ceramide lipid anchor attached to a carbohydrate chain featuring two sialic acid residues. This unique structural combination classifies it as a ganglioside, specifically a disialoganglioside, embedded primarily in the outer leaflet of the plasma membrane of certain cells. Its biochemical nature makes GD2 highly hydrophobic due to the lipid component, while its carbohydrate and sialic acid moieties impart strong biological recognition properties.

GD2 is naturally expressed at low levels in normal tissues but is overexpressed on the surface of certain tumor cells, including neuroblastoma, melanoma, and small-cell lung cancer. This tumor-associated ganglioside characteristic underpins its significance as a biomedical research target, especially in oncology.

Role in Biomedical Research

GD2 plays a vital role in cancer research glycolipids as a biomarker distinguishing malignant cells. Its prevalence on tumor cells but limited presence in healthy adult tissues makes it an excellent candidate for targeted therapies. Researchers focus heavily on GD2 for studying tumor biology, cell signaling pathways, and immune evasion mechanisms in cancers like neuroblastoma and melanoma.

Moreover, GD2’s distinct molecular structure aids researchers in designing monoclonal antibody therapies and developing immunotherapy strategies aiming to selectively target and destroy cancer cells while sparing normal tissues. This has propelled GD2 into the spotlight for experimental vaccines, antibody-drug conjugates, and chimeric antigen receptor (CAR) T-cell therapies.

Importance as Oncology Biomarker

GD2 serves as a critical biomarker in oncology due to its high specificity and sensitivity for neuroblastoma and other cancers. Its expression level correlates with tumor aggressiveness and disease progression, offering valuable diagnostic and prognostic insights. Laboratories and clinical trials frequently utilize GD2 detection for:

• Early cancer diagnosis
• Monitoring treatment response
• Guiding personalized immunotherapies

disialoganglioside GD2 is a key biomarker and therapeutic target in cancer research and treatment, making high-purity GD2 glycolipid indispensable for biomedical labs and pharmaceutical development in the United States market.

Physical and Chemical Properties of Disialoganglioside GD2

Appearance and Purity Grade

Disialoganglioside GD2 (CAS 65988-71-8) is typically supplied as a white to off-white lyophilized powder or a fine crystalline solid. It meets a high purity grade, generally exceeding 98% purity, ensuring it is suitable for sensitive biomedical and research applications, particularly in cancer and immunotherapy studies.

Solubility

GD2 ganglioside is soluble in organic solvents such as methanol, chloroform, and dimethyl sulfoxide (DMSO). It shows limited solubility in water, which is common for glycolipids due to their hydrophobic ceramide backbone. Proper solvent selection is essential when preparing solutions for biochemical assays or immunological profiling.

Stability

This tumor-associated glycolipid displays good chemical stability under recommended storage conditions. However, it is prone to degradation upon prolonged exposure to moisture, light, or elevated temperatures. To maintain integrity and biological activity, avoid repeated freeze-thaw cycles and protect from direct sunlight.

Storage Conditions

For optimal stability, store Disialoganglioside GD2 at -20°C in a dry, well-sealed container. Use desiccants to minimize moisture exposure. Once reconstituted, solutions should be used promptly or stored at low temperatures (4°C) for short terms, depending on solvent compatibility.

Molecular Formula and Structure

Disialoganglioside GD2 has the chemical formula C74H134N4O32. Structurally, it belongs to the class of glycolipids, featuring two sialic acid residues contributing to its disialoganglioside classification. Its amphipathic nature, combining a hydrophobic ceramide base with hydrophilic sugar residues, makes it crucial for membrane interactions and immunological recognition.

By understanding these physical and chemical properties, researchers and pharmaceutical developers can effectively incorporate GD2 ganglioside into cancer research, immunotherapy, and biomarker development workflows, ensuring reliable results and reproducible findings.

Applications and Uses of Disialoganglioside GD2 CAS 65988-71-8

Disialoganglioside GD2 is a vital glycolipid extensively used in cancer research and biomedical studies due to its strong association with tumor cells, particularly in neuroblastoma and other solid tumors. Here’s how GD2 is applied across various fields:

Cancer Research and Immunotherapy Development

• Tumor-Associated Ganglioside Target: GD2 is a well-known biomarker on the surface of certain cancer cells, especially in neuroblastoma, melanoma, and small-cell lung cancer. It helps researchers identify tumor presence and progression.
• Immunotherapy: GD2’s prominent expression in tumors makes it a prime target for developing immunotherapies, including monoclonal antibodies and CAR-T cell therapies aimed at selectively attacking cancer cells while sparing normal tissue.
• Monoclonal Antibody Therapies: Many antibody-based treatments are designed to bind specifically to GD2, improving the precision and efficacy of cancer treatments.

Ganglioside Profiling and Biochemical Studies

• Glycolipid Analysis: Researchers utilize high-purity GD2 for studying ganglioside composition in brain tissues and tumor microenvironments to better understand cellular signaling and cancer cell biology.
• Biochemical Research: GD2 serves as a model molecule for investigating ganglioside structures and functions in the nervous system and tumors, aiding in the discovery of new therapeutic targets.

Pharmaceutical Target and Diagnostic Development

• Biomarker Development: GD2’s reliable presence on tumor cells makes it crucial for diagnostic assays and early cancer detection tools.
• Pharmaceutical Research: The compound supports the creation of targeted drug delivery systems that use GD2 ligands to concentrate treatments directly at tumor sites.
• Diagnostics: GD2 is used in laboratory tests to monitor disease progression and evaluate treatment responses, enhancing personalized medicine approaches.

of GD2 Applications

Application Area	Description
Cancer Research	Tumor marker identification and study
Immunotherapy Development	Target for antibody and CAR-T therapies
Ganglioside Profiling	Analysis of glycolipid patterns in tissues
Biochemical Studies	Understanding ganglioside roles in cancer
Pharmaceutical Targeting	Development of GD2-specific drugs and delivery
Diagnostics and Biomarkers	Tools for cancer detection and monitoring

Disialoganglioside GD2 CAS 65988-71-8 is therefore a key compound in the US market for researchers and pharmaceutical developers focused on oncology and neurological diseases, supporting critical advancements in targeted cancer therapies and diagnostics.

Quality Assurance and Compliance for Disialoganglioside GD2

Manufacturing Standards and Regulatory Compliance

We follow strict manufacturing standards to ensure every batch of Disialoganglioside GD2 (CAS 65988-71-8) meets the highest quality expectations demanded by the US biomedical and pharmaceutical industries. Our production process aligns with current Good Manufacturing Practices (cGMP), helping guarantee product consistency, purity, and safety.

Analytical Techniques for GD2 Ganglioside

To validate the identity and purity of GD2 glycolipid, we employ advanced analytical techniques, including:

• High-Performance Liquid Chromatography (HPLC) – for assessing purity and detecting impurities.
• Mass Spectrometry (MS) – confirms molecular weight and structural integrity.
• Nuclear Magnetic Resonance (NMR) Spectroscopy – verifies molecular structure and composition.
• Thin Layer Chromatography (TLC) – used for qualitative analysis during intermediate production steps.

These methods ensure that our tumor-associated disialoganglioside GD2 meets or exceeds industry standards essential for cancer research and immunotherapy applications.

Certificate of Analysis

Every shipment of GD2 ganglioside is accompanied by a detailed Certificate of Analysis (CoA). This document includes:

• Batch number and production date.
• Confirmation of chemical identity and molecular formula.
• Purity level, typically exceeding 98% for research-grade.
• Results from all relevant analytical testing.
• Storage recommendations and handling information.

This transparency helps researchers and pharmaceutical developers confidently use our GD2 glycolipid in their critical work.

Packaging and Labeling

Disialoganglioside GD2 is packaged to preserve its stability and high purity throughout transit and storage. Our packaging typically includes:

• Sealed amber glass vials or bottles to protect from light and moisture.
• Tamper-evident caps and moisture barrier seals.
• Clear, compliant labeling showing product name, CAS 65988-71-8, batch number, and storage instructions.

We understand the importance of proper packaging in ensuring the ganglioside’s functionality for sensitive applications like immunotherapy development and diagnostics.

By maintaining rigorous quality assurance and compliance protocols, we provide a reliable supply of high-purity GD2 ganglioside suited for the demanding needs of US cancer research and pharmaceutical industries.

Ordering Information for Disialoganglioside GD2 CAS 65988-71-8

When you’re ready to order Disialoganglioside GD2 (CAS 65988-71-8), we offer flexible options designed to fit your research or production needs. Whether you require high-purity GD2 for cancer research, immunotherapy development, or biochemical studies, we have you covered.

Package Sizes and Bulk Supply

• Standard package sizes range from milligram to gram quantities, perfect for lab-scale research and testing.
• For larger needs, we provide bulk supply options to support pharmaceutical development and commercial-scale projects.
• Custom packaging is available to help you manage storage and handling efficiently.

Pricing and Availability

• Competitive pricing is offered on all package sizes, reflecting the high purity and reliability of our GD2 ganglioside.
• Pricing can vary based on quantity and packaging preferences.
• We maintain consistent stock levels to ensure fast order processing and fulfillment.

Lead Time and Delivery Options

• Typical lead times range from 3 to 7 business days, depending on order size and customization.
• Expedited shipping options are available for urgent needs within the United States.
• We partner with trusted carriers to ensure safe and timely delivery direct to your facility or lab.

Custom Synthesis Services

• If your project requires tailored GD2 derivatives or modified gangliosides, we offer custom synthesis and formulation services.
• Our chemical manufacturing expertise includes working with complex glycolipids like GD2 to meet your exact specifications.
• Discuss your project goals with our team for a personalized quote and timeline.

By providing multiple ordering options, transparent pricing, and reliable delivery, we support your work in cancer research, diagnostics, and immunotherapy development with high-quality disialoganglioside GD2.

For more detailed product specifications or to place an order, please contact our sales team today.

Safety and Handling of Disialoganglioside GD2 CAS 65988-71-8

Working safely with Disialoganglioside GD2 (CAS 65988-71-8) is essential to maintain product integrity and protect user health. Here’s what you need to know about its safety, handling, storage, and disposal.

Safety Data Sheet Overview

Always consult the Safety Data Sheet (SDS) before using GD2 ganglioside. The SDS provides detailed information on hazards, first aid measures, personal protection, and emergency procedures related to this chemical. Keep it accessible in your lab or facility for quick reference.

Handling Precautions for GD2 Glycolipid

• Wear proper personal protective equipment (PPE): gloves, lab coat, and eye protection are mandatory.
• Avoid inhalation, ingestion, and direct skin or eye contact.
• Handle GD2 ganglioside in a well-ventilated area to minimize exposure to dust or vapors.
• Use appropriate tools and techniques to prevent contamination or spills during transfer and measurement.
• Keep the product away from incompatible materials like strong oxidizers to maintain stability.

Storage Guidelines for GD2 CAS 65988-71-8

• Store in a cool, dry place away from direct sunlight.
• Keep the container tightly sealed when not in use to avoid moisture absorption and degradation.
• Ideal storage temperature typically ranges between 2–8°C, but always follow specific manufacturer recommendations.
• Avoid temperature fluctuations to maintain high purity and biological activity of the ganglioside.

Disposal Instructions

• Dispose of unused or expired GD2 and contaminated materials according to local, state, and federal regulations.
• Treat as a potentially bioactive chemical waste due to its use in biomedical and cancer research applications.
• Use licensed chemical waste disposal services to ensure environmental safety and regulatory compliance.
• Avoid flushing or dumping the product down drains or general waste streams.

By following these safety and handling best practices, you protect yourself and others while maintaining the quality and effectiveness of this critical tumor-associated glycolipid for research and development.

About Blissam GD2 Ganglioside Supplier

Company Introduction and Expertise

At Blissam, we specialize in supplying high-quality Disialoganglioside GD2 (CAS 65988-71-8) and other critical biochemical raw materials. As a trusted GD2 ganglioside supplier in the United States, we leverage decades of experience in chemical manufacturing and raw material sourcing. Our focus is on providing reliable, pure, and consistent products designed to meet the strict demands of cancer research, immunotherapy development, and related biomedical applications.

Quality Commitment for GD2 Ganglioside

Quality is at the core of what we do. Our GD2 glycolipid undergoes rigorous testing and quality assurance processes to ensure high purity, stability, and batch-to-batch consistency. We follow stringent manufacturing standards aligned with industry best practices, ensuring the GD2 ganglioside glycolipid you receive is ready for advanced research or pharmaceutical use. Every batch comes with a comprehensive Certificate of Analysis (CoA) to back up our quality claims.

Customer Service and Support

We understand that selecting and handling a specialized product like Disialoganglioside GD2 requires expert guidance. That’s why Blissam offers dedicated technical support to help you with your ordering choices, application tips, and troubleshooting. Our customer service team is quick to respond and committed to ensuring your experience is smooth—from inquiry to delivery.

Contact and Technical Support

Whether you need detailed product information, custom synthesis options, or bulk supply for your research or manufacturing needs, Blissam is ready to assist. Reach out anytime via phone, email, or our website contact form. Our technical experts are available to provide tailored advice on GD2 ganglioside use in immunotherapy, cancer diagnostics, and biochemical studies.

Choose Blissam for dependable GD2 ganglioside supply and expert support you can count on.

FAQs and Customer Support for Disialoganglioside GD2 CAS 65988-71-8

Purity and Quality Assurance

What purity level does your GD2 ganglioside meet?

Our Disialoganglioside GD2 (CAS 65988-71-8) is supplied at high purity levels, typically above 98%, ensuring reliability for cancer research and immunotherapy applications. Detailed purity reports are available in the Certificate of Analysis provided with each batch.

Application Support

Can you advise on how to use GD2 in immunotherapy research?

Absolutely. We offer technical support for using GD2 ganglioside as a target in monoclonal antibody therapies and ganglioside profiling. We understand the critical role of GD2 in neuroblastoma biomarker studies and can guide you on optimal handling, solubility, and storage for your experiments.

Shelf Life and Storage

How long does the GD2 ganglioside remain stable?

When stored under recommended conditions—cool, dry place at -20°C or below—our GD2 maintains its stability for up to 12 months. We advise minimizing freeze-thaw cycles to preserve its biochemical integrity.

Technical Inquiries

Who can I contact for detailed technical questions?

Our dedicated technical support team is available to assist with any product-specific questions, including solubility profiles, formulation guidance, and analytical method recommendations. Reach out via the contact details below for prompt, expert help.

Contact Information

• Phone: +86 15957191858
• Email: info@blissamchem.com
• Live Chat: Contact Us

We prioritize fast responses to help you stay on track with your research and product development involving GD2 ganglioside.

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We offer a broad selection of high-purity gangliosides, including other key glycolipids closely related to Disialoganglioside GD2. These molecules are essential for cancer research, immunotherapy studies, and biochemical profiling. Our lineup covers various gangliosides that support comprehensive tumor-associated glycolipid analyses.

Antibodies Against GD2

Our catalog includes monoclonal and polyclonal antibodies targeting GD2 ganglioside, ideal for diagnostic and therapeutic research. These antibodies are widely used in neuroblastoma biomarker detection, immunotherapy development, and pharmaceutical assays. They come with verified specificity, ensuring reliable results in both clinical and research settings.

Custom Synthesis Options

To meet specialized research needs, we provide custom synthesis services for GD2 ganglioside and related compounds. This service allows tailored modifications, scale adjustments, and purity specifications, helping researchers and biotech companies advance their projects without compromise. Our synthesis process meets stringent quality control standards, supporting consistency and reproducibility.

By choosing our products, you gain access to a trusted supplier dedicated to supporting cancer research glycolipids, including essential GD2 ganglioside materials backed by expert technical support and fast delivery tailored to the US market.